I've done everything from calorie-counting diets from my doctor to Weight Watchers, Nutri-System, various portion-control diets and adopting a low-carb, lifestyle change approach that I followed for 7-1/2 years. It ultimately failed for me, but mostly because I went through a huge period of stress in my life and started binge eating.
I lost 100 lbs last year by going to a 12-Step program for Food Addicts (www.foodaddicts.org) which is working extremely well for me. I haven't felt hungry and am really enjoying all the new foods I'm trying (quinoa is a new favourite). The true test will be when I get to maintenance, but my hope lies in seeing many, many people in the meetings who have lost all their weight and kept it off for years. The support system and incentive to keep eating "abstinently" are amazing motivators – something that was missing from every other program I tried. The support was there in those programs in theory, but in this program it really is put into action in a very effective way.
I have about 30 lbs left to lose to reach my goal, and I know that if I just keep going back to the meetings and calling my sponsor, I WILL reach goal and I WILL keep the weight off.